When activated, these receptors trigger several beneficial effects: Enhanced insulin secretion The pancreas releases insulin in response to elevated blood glucose levels, but only when needed (glucose-dependent mechanism) Reduced glucagon release Glucagon, which raises blood sugar, is suppressed when glucose levels are adequate Delayed gastric emptying Food moves more slowly from the stomach into the intestines, promoting satiety Appetite regulation Signals to the brain's appetite centres reduce hunger and food intake Unlike naturally occurring GLP-1, which is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes, pharmaceutical GLP-1 receptor agonists are chemically modified to resist this degradation
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doi: 10.1016/j.appet.2009.01.003 105 BerthoudHRMnzbergHMorrisonCD
This slow titration minimizes gastrointestinal side effects, which are the most commonly reported adverse events with all GLP-1 receptor agonists
Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor
08743540158 - Iscritta al Registro Imprese di Bergamo - REA 244649 Capitale sociale sottoscritto e versato 11.170.960
