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Hemoconcentration: Dehydration reduces plasma volume, leading to hemoconcentration with higher concentrations of red blood cells and clotting factors, accelerating clotting processes

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However, healthy individuals synthesise glutathione endogenously at rates sufficient to meet this demand if dietary intake of cysteine, glutamate, and glycine is adequate

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Avoid doubling the dose

For example, instead of 5 mg once weekly, someone might inject 2.5 mg twice weekly, separated by 3 to 4 days