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FIGURE 1 2.1 Iron metabolism imbalance Iron, an essential trace element, primarily participates in metabolic processes in the forms of Fe 2+ and Fe 3+ ( 2+ absorbed in the intestines or released from erythrocyte degradation is oxidized to Fe 3+ by ceruloplasmin (CP) in the circulation

Notably, ultrasonography or DECT reveals urate crystal deposition in 15%40% of asymptomatic hyperuricemic patients, indicating subclinical gout risk (Xiang et al., 2024

This pathway accounts for around 70% of PC synthesis in the liver (Vance 2014)

So, changes in these redox ratios with aging or dietary interventions exert widespread effects on cellular metabolism (Veech et al., 2019)