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These peptides act as signaling molecules, influencing everything from hormone production and cell regeneration to immune function and cognitive health

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In addition to medications, making lifestyle changes can significantly impact liver health: Diet: A balanced diet rich in fruits, vegetables, and whole grains can support liver function

For example, intradiscal injection of bone morphogenetic protein-2 (BMP-2) induced degenerative changes [92] and weekly intradiscal treatment with growth and differentiation factor-5 (GDF-5) or insulin-like growth factor-1 (IGF-1) resulted in inflammatory reactions in the adjacent vertebrae and connective tissue infiltrates in the NP, causing the IVD to collapse [93]

Recovery from injury or surgery may be worse

Post-illness shedding or major weight loss