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This nano-PROTACs effectively suppressed aerobic glycolysis by downregulating cellular myelocytomatosis viral oncogene homolog (c-Myc, a critical regulator of glucose metabolism), and concurrently inhibited the expression of programmed death-ligand 1 (PD-L1), thereby improving the chemotherapeutic effect of DOX

10.1042/CS20160349 110 SuX.ZhangM.QiH.GaoY.YangY.YunH.et al (2022)

Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance

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Despite weight regain after retatrutide withdrawal, the anti-tumor benefits of the compound persisted suggesting the effects may not be purely a function of weight loss

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