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Peptide therapy involves using short chains of amino acids-often administered by injection or topically-to target specific pathways in the body

Pharmaceutics 15:1916 Wang Y, Ni M, Huang M, Xing L, Liu X, Jia F, Huang Y (2025) Regulation of nanoparticle exocytosis direction via receptors transfer: a novel strategy to enhance therapeutic efficacy of semaglutide

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As an enzymatic cofactor in the synthesis of monoamine neurotransmitters, including serotonin and dopamine, reduced BH4 levels contribute to decreased 5-Hydroxytryptamine (5-HT) and dopamine (DA) levels, which induces depressive-like behaviors (Nasser et al., 2014