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Furthermore, clinical trials have shown that standard NRT doses are inadequate for rapid metabolizers of nicotine (i.e., those who inactivate nicotine to cotinine and then to 3-hydroxycotinine [3-HC] more quickly than others due to genetic variation affecting the activity of the hepatic enzyme CYP2A6) [20, 25]
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NNAL 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol is a Tobacco-Specific Nitrosamine (TSNA), which are a group of carcinogens found in tobacco and tobacco smoke
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