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In addition to enzymatic L-lactylation utilizing lactate as a lactyl donor and involving enzymes including writers (lactyltransferases), readers (lactylation-binding enzymes), erasers (delactylases), and lactyl-coenzyme A (lactyl-CoA) synthases, non-enzymatic D-lactylation derived from the glyoxalase II substrate S-D-lactoylglutathione (SLG) has also been identified

This indicates an additional adaptive response by the body that becomes more responsive to leptins signals, promoting satiety and improved appetite control, even with less leptin present

9 The effects of high-protein diets remain controversial