No, anxiety is not listed as a recognized adverse effect in FDA prescribing information for Zepbound, and clinical trials did not show significantly higher anxiety rates compared to placebo
(A, B, C) Cells were pretreated with or without GLP-1 (10 nM) for 1 h in the presence or absence of Ex-9 (10 nM), then incubated with H 2 O 2 (1 mM) for 12 h, expressions of phosphorylated Akt and ERK1/2 were detected by Western blot
The normal pancreatic duct epithelial cells were always GLP1R negative, irrespective of whether the samples originated from insulinomas, chronic pancreatitis, or ductal pancreatic carcinoma samples
Some patients may transition to other treatments if their condition improves significantly, but this is less common
Of note, Mounjaro was most commonly used to support weight loss
When treating patients with NAFLD, management should address not only the risk of progressive liver disease but also cardiometabolic risk factors to control cardiovascular disease risk