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& Markovich, D
Nunes, E
4 Not only are GLP-1 and similar drugs highly effective at their original purpose of controlling blood sugar for diabetes, they are also much more effective than any previous weight loss medications
However, glucagon itself has recently been shown to be able to stimulate insulin secretion from the perfused mouse pancreas by a mechanism which appears to involve an interaction with GLP-1 receptors (since the effect was attenuated by exendin 9-39) (111), complicating assessment of the relative importance of any locally produced GLP-1
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