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199 For smokers who could not cut down significantly by using the NRT patch, combining extended-release bupropion and varenicline was more effective than placebo, particularly for men and those who were severely nicotine dependent

Nicotine replacement therapy (NRT) can provide you with a low level of nicotine without the tar, carbon monoxide and other dangerous chemicals present in cigarettes and reduce the unpleasant withdrawal effects

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"We were trying to find new drugs to treat depression