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Sterile water is appropriate only for single-use reconstitution where the entire vial will be used in one injection

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The Phase 2 retatrutide trial (PMID 37366315) reported -24.2% body weight change at the 12 mg weekly dose across 48 weeks

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This theory is often referred to as the methyl trap hypothesis. In simple terms, folate may help improve certain blood markers associated with anemia even when vitamin B12 levels remain low