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Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression

INTRODUCTION At a population level, obesity is driven by an increase in the intake of easily available, energy-dense, highly palatable foods and a decrease in physical activity at school/work and in leisure time

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Extracellular insulin can activate Insulin receptor tyrosine kinase, which results in the phosphorylation of IRS1, and AKT is subsequently activated

For a deeper look at this relationship, see our guide on gut microbiome, circadian rhythm, and metabolic balance