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Monitoring kidney and liver function is essential because semaglutide is metabolized in the liver and excreted by the kidneys

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As formation of GPCR oligomers can influence coupling to signalling intermediates (Milligan et al., 2019), including for GLP-1R (Harikumar et al., 2012

While it comes with some potential side effects , most are mild, temporary, and manageable especially when starting with a low dose and following best practices