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1 READ MORE: GLP-1 Agonists Associated with Doubled Risk of Neovascular AMD, Study Finds NAION moves the discussion beyond the retina A 2024 matched cohort study reporting increased NAION incidence among semaglutide-prescribed patients drew wide attention across ophthalmology, prompting debate over whether the association reflects a true optic nerve safety signal or the underlying vascular risk profiles of diabetic and obese populations

Consistently, oxygenglucose deprivation (OGD) was found to activate the same TLR4p38 MAPK pathway, resulting in elevated malondialdehyde (MDA) accumulation and neuronal ferroptosis

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Compounded semaglutide is a customized version of the GLP-1 (glucagon-like peptide-1) medication semaglutide, made by compounding pharmacies to suit individual needs