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Compounded (Semaglutide/Tirzepatide): Because compounded medications are drawn from a vial into a syringe, they offer more flexibility for super responders who may be too sensitive to standard doses

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semaglutide is a GLP-1 agonist only this explains tirzepatides superior weight loss Clinical evidence consistently favours Mounjaro: ~double the weight loss at 12 months in real-world data Side effects are similar for both primarily gastrointestinal, worst during dose escalation, improving over time Critical interactions: oral contraceptives, insulin, sulfonylureas, and warfarin Both are contraindicated in personal/family history of MTC or MEN 2, and during pregnancy Brand-name costs exceed $1,000/month without insurance

Tirzepatide: Demonstrated approximately 21-22% body weight reduction in 72-week trials