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This process culminates in the exertion of an oncogenic effect, the enhancement of glutamine metabolism, and the promotion of CRC cell proliferation [42]

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It can be triggered by inhibiting AMPKmTOR signaling, overexpressing Wnt9a activating p21 or the Wnt-catenin pathway (203)

For the DDD-Ube2e2-COP1-c-Jun-STK40 complex, the purified protein was prepared at a concentration of 0.52 mg/ml and mixed with 0.02% N-Octyl--D-glucopyranoside (OG) prior to cryo-EM grids preparation to mitigate the effects of preferred orientation of the particles

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