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10.1038/cr.2016.157 38 ShaJ.HanQ.ChiC.ZhuY.PanJ.DongB.et al (2018)

Avoid Overexertion Pushing your muscles too hard can lead to cramps

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Intriguingly, our study showed that GSDMD-mediated pyroptosis in endothelial cells had no significant effects on endothelial function and angiogenesis, while the inhibition of macrophage pyroptosis impaired endothelial function and in vitro angiogenesis, which was determined by the co-cultural incubation of THP-1 cells and HUVECs

These intestinal changes were accompanied by region-specific neuroimmune alterations in the amygdala and medial prefrontal cortex, highlighting the close communication between the gut and the brain

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