Studies in primary endothelial cells grown in culture, as well as in animal models illustrate that a deficiency of GPx1 alters endothelial dependent vasodilation by regulating bioavailable nitric oxide [39, 60, 61, 70, 71]
Intranasal administration bypasses the blood-brain barrier via the olfactory nerve and trigeminal pathways, allowing direct delivery to the CNS within minutes
Methylcobalamin is more effective than cyanocobalamin because it requires less cellular processing
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revealed that in aqueous media, chicken erythrocyte histone H5 is mostly disordered (it is essentially in the form of a flexible random coil) but the N-terminal part of this protein gains globular helical structure in the presence of salts (Crane-Robinson et al., 1976)
May 2008;3(3):691-698