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Abbreviations PCOS: Polycystic ovarian syndrome SHBG: Sex-hormone binding protein MI: Myo-inositol IVF: In vitro fertilization ICSI: Intracytoplasmic sperm injection DCI: D-chiro-inositol IPG: Inositolphosphoglycan GPI: Glycosylphosphatidylinositol PP1: Phosphoprotein phosphatase 1 HDL: High density level SOD: Superoxide dismutase GSH: Glutathione FSH: Folliculostimulating hormone AMH: Anti-Mllerian hormone LH: Luteinizing hormone MET: Metformin ART: Assisted reproductive technology Ca ++ : Calcium ion GnRH: Gonadotropin releasing hormone ROS: Reactive oxygen species OR: Odds-ratio 95% CI: Confidence interval at 95 References Merviel P, Boue S, Mnard M, Le Martelot MT, Roche S, Lelivre C, et al

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Studies suggest that the VEGF/VEGFR-2 pathway may be particularly relevant, as its activation seems to trigger intracellular signaling cascades that potentially influence endothelial cell migration, proliferation, and survival