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The association of the variant GPX4 genotypes with the increased risk of CS in hypertensives remained statistically significant after adjusting for confounding variables such as sex, body mass index (BMI), blood pressure and antihypertensive medication use (OR=2.18, 95%CI 1.463.27, P =0.0015)

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Cardiovascular and Kidney Outcomes No dedicated prospective RCT has yet been powered to compare combined SGLT2i and GLP-1RA therapy versus monotherapy for cardiovascular and kidney endpoints, although the ongoing PRECIDENTD trial is expected to address this gap [36]

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