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Wegovy is approved for long-term weight management in people with obesity or overweight who have related health conditions

TNF is an immune signaling molecule that plays a pivotal role in modulating synaptic mechanisms in the brain

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Kapantais et al

Accordingly, the list of molecules which have been shown unequivocally to be physiological substrates of DPP-4 is short (37, 38)

In diet-induced obese mice showing MASLD, the principal component analysis demonstrated that the combination of SGLT2i and GLP1-RA showed more potent beneficial effects on MASLD than SGLT2i and dipeptidyl peptidase-4 inhibitor 17