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Despite the promising findings reported in preclinical studies, it is important to emphasize that the majority of the available evidence originates from animal models and cell culture experiments

Diet Recommendations for IGF1 rs35767 and the IGF-1 LR3 Pathway A targeted nutritional approach for the IGF1 rs35767 variant focuses on supplying the micronutrients and macronutrient balance that support muscle protein synthesis, growth factor signaling, and recovery capacity and reduce the metabolic burden on pathways connected to IGF-1 LR3

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This theory matches data from the German prospective multicenter study ALLIVE including 22 MDS and 90 AML patients and some smaller studies, which show an increase in NTBI and LIP levels during allogeneic HSCT ( During the course of AML, signs of iron overload have also been described

Bull Exp Biol Med 163(5):671676

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