More recently, Laffer et al, have demonstrated the activation of the complement pathway in FD, demonstrated in patients with missense and nonsense mutations, both before and after ERT (33)
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However, to clearly understand the mechanisms and level of toxicity of sALS astrocytes, it remains to be investigated if sALS and fALS astrocytes are equally detrimental to motor neurons upon activation [in response to an ALS environment or to lipopolysaccharide (LPS)] and their secretion pattern in such a context
BPA and BPS exposure have been tied in numerous studies to metabolic dysfunction and obesity
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