Yes , and this is closely related to the widely discussed phenomenon known as Ozempic Face. Ozempic Face describes the gaunt, hollow, or prematurely aged facial appearance that can follow rapid, significant weight loss on GLP-1 medications
These cells release the peptides growth hormone-releasing hormone (GHRH or somatocrinin ) and growth hormone-inhibiting hormone (GHIH or somatostatin ) into the hypophyseal portal venous blood surrounding the pituitary
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Some studies indicate that hydrocortisone can promote neurogenesis and neuronal survival while increasing synaptic plasticity, thereby enhancing cognitive abilities (Dinse et al., 2017)