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Proponents argue this maintains more stable tissue levels, though others find once-daily dosing equally effective with better compliance

Although CVB downregulates class I HLAs, cells still present HLA bound viral peptides that mostly map to the P2-C protein and are conserved across CVB1 and CVB3 ( Moreover, CVB was shown to persistently infect a human pancreatic ductal cell line ( CVB-associated T1D may also be caused by the viral-associated effects on central tolerance

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