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Glutathione S-transferase A2 (GSTA2) which is a phase II detoxifying enzyme is highly expressed in the liver tissue functioning in detoxification of electrophilic compounds, such as products of oxidative stress [16]
4.2.1 Metformin Metformin demonstrated efficacy in blocking the increase of fatty acid transport protein CD36, along with aberrant ceramide and diacylglycerol content in the skeletal muscle of diabetic rats (126)
Johnson WM, WilsonDelfosse AL, Mieyal J
Stress, overeating, and obesity: Insights from human studies and preclinical models: Maria Razzolia, Carolyn Pearson, ScottCrow, Alessandro Bartolomuccia