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However, under more extreme conditions such as: 1) inadequate intake of foodstuffs containing the antioxidants, 2) excessive intake of pro-oxidants, 3) exposure to noxious chemicals or ultraviolet light, 4) injury/wounds, and/or 5) intense exercise, especially eccentric exercise, the body's endogenous antioxidant system is not able to effectively remove excessive ROS production[2]

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Confounding variables, heterogeneity in study designs, and population-specific differences may influence observed outcomes

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Although most mouse models of adult-onset HD have not been analysed for changes in DA levels during pre-symptomatic stages 9 , the transgenic rat model (SPRDtgHD) expressing human m HTT with 51 CAG repeats 7 exhibits DA dynamics similar to Trkb Penk -KO mutants and is reminiscent of human HD

J Hepatol 40(5):781786