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While the expression in the granulosa cells of three genes involved in oocyte quality (PGK1, RGS2 and CDC42) was found to be significantly increased in the MI + folic acid group, no significant difference was reported in the concentration of reactive oxygen species (ROS) in the follicular fluid, suggesting that the effect of MI on oocyte quality is independent of its antioxidant action

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Throughout the study period, the following drugs maintained fewer than 0.02 million monthly prescriptions: Alli (orlistat) by Haleon