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The mechanism of action operates on multiple levels

However, safety continues to be a concern as there have been reports of adverse reactions, which range from mild, transient headaches and skin eruptions to severe drug reactions requiring hospitalization

DOI: 10.1113/jphysiol.1934.sp003147 Gericke A et al (2011): Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

The study began by collecting blood samples from the jugular veins of fourth-month old, male Sprague-Dawley rats