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AGEs can be taken exogenously, through the consumption of food and smoke, or produced endogenously

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GLP-1RAs exert their effects by activate GLP-1 receptors, thereby enhancing insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appetite

The study, presented at the European Congress on Obesity, found that even for those taking newer, higher-dose weight loss drugs such as Wegovy and Mounjaro, people put weight back on once they stopped treatment