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A peptide with reduced acidity was designed for increased cell permeability The p53 TAD2 sequence exhibited a highly negative charge, whereas the p53 binding interface of the FOXO4 FHD contains several positively charged residues

A mostly-full vial that was warm for 30 hours may still have acceptable potency for a few more doses, but do not rely on it for the remaining weeks of the expected shelf life

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By 40, we have lost over 25% of it