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In rats with collagen-induced arthritis, activation of the Wnt/-catenin signaling pathway was triggered by TNF-, leading to a concomitant upregulation of -SMA and cadherin-11 (CAD-11) expression in synovial fibroblasts (179)

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The precise mechanisms by which GLP-1 receptor agonists may trigger headaches are not fully elucidated , but several plausible physiological explanations exist