Based on the damage to thyroid cells caused by low Se level, researchers have raised the possibility that Se supplementation may be beneficial in GD and have conducted a series of clinical studies (2830)
most were non-serious and mild or moderate in nature
10.3390/ma12081311 88 HuQ.LiH.ArchibongE.ChenQ.RuanH.AhnS.et al (2021)
GGT also identifies liver and brain dysfunction tied to poor diet, alcohol, tobacco, and inactivity
281,282 Liver-specific KO of upstream Hippo kinases, including MST1/2, LATS1/2, and the adaptor proteins SAV1 and MOB1a/b, leads to decreased YAP phosphorylation and increased nuclear translocation
Mechanistically, its claimed effects track the biology of that TB4 motif: regulating actin dynamics, driving cell migration, and supporting new vessel growth and tissue repair