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H.p cooperates with S.m to promote caries, enhances the virulence and inflammatory response of P.g in periodontitis, and survives within C.a , which provides it with shelter, helping it resists environmental stresses and antibiotics, thereby aiding its persistence and reinfection (Fan et al., 2025)

In addition, simultaneous YAK1 -OE and CYS4- OE showed additive effect on methionine auxotrophy (Figure 1D)

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The World Health Organization (WHO) includes glutathione in its list of essential medicines, acknowledging its critical role in supporting various bodily functions