In summary, the chemical synthesis method for synthesizing tripeptides requires multiple steps, including protecting groups, activating, condensing, deprotecting groups, and modifying
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Human fecal samples 280 fecal samples were obtained from 70 healthy adults (35 participants per arm)
Where available, endoscopic data including tissue biopsies were collected
In certain embodiments, tonicity agents are added to the formulations described herein in an amount as to provide a practical osmolality of an otic formulation of about 100 mOsm/kg to about 1000 mOsm/kg, from about 200 mOsm/kg to about 800 mOsm/kg, from about 250 mOsm/kg to about 500 mOsm/kg, from about 250 mOsm/kg to about 350 mOsm/kg, or from about 280 mOsm/kg to about 320 mOsm/kg
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