Moreover, ROS can also abstract hydrogen atoms adjacent to the double bonds of PUFAs to form lipid radicals, which then combine with oxygen to generate lipid peroxyl radicals, further triggering chain reactions [62, 63]
Gzeldere, H
NAC : Boosts glutathione production in the liver and has been widely used in hospitals to treat acetaminophen (Tylenol) overdose , which causes liver damage
The larvae were cleaned with 0.2 % sodium hypochlorite solution to remove the adherent bacteria and then finally used for the in vitro larval mortality assay[68]
Oral drops, less large-scale data
Glossary GPX4 glutathione peroxidase 4 TF transferrin TFR1 transferrin receptor 1 STEAP3 six-transmembrane epithelial antigen of the prostate 3 ALOX arachidonate lipoxygenases HMOX1 heme oxygenase 1 HNE 4-hydroxynonenal MDA malondialdehyde LOOHs lipid hydroperoxide AA arachidonic acid AdA adrenic acid ACSL4 long-chain acyl-CoA synthetase 4 PE phosphatidylethanolamine H 2 O 2 hydrogen peroxide Fe 2+ ferrous iron Fe 3+ ferric iron NOX NADPH oxidase PUFAs polyunsaturated fatty acids PLOOH phospholipid hydroperoxides LOX lipoxygenase GSH glutathione System x c cysteine/glutamate antiporter xCT/SLC7A11 solute carrier family 7 member 11 FSP1 ferroptosis suppressor protein 1 CoQ1 coenzyme Q10 NAD(P)H nicotinamide adenine dinucleotide phosphate CoQH2 Coenzyme Q10 BH4 dihydrofolate to tetrahydrofolate Nrf2 nuclear factor erythroid 2-related factor 2 Keap1 Kelch-like ECH-associated protein 1 ARE antioxidant response elements GCL glutamate cysteine ligase GSS glutathione synthetase HO-1 heme oxygenase-1 USP7 ubiquitin-specific protease 7 SAT1 spermidine/spermine N1-acetyltransferase 1 IPP isopentenyl pyrophosphate MVA pathway mevalonate pathway GCLC glutamate-cysteine ligase catalytic subunit -KG -ketoglutarate VDAC2/3 voltage-dependent anion channels2/3 ETC electron transfer chain ROS reactive oxygen species STAT3 transcription 3 Fer-1 ferroptosis inhibitor ferrostatin-1 GRh3 Ginsenoside Rh3 GRh4 Ginsenoside Rh4 GRg5 Ginsenoside Rg5 GRK1 Ginsenoside RK1 GCK Ginsenoside CK NCOA4 nuclear receptor coactivator 4 NR3C1 nuclear receptor subfamily 3 group C member 1 FOXO1 forkhead box protein O1 PLOO phospholipid peroxyl radicals AMPK activated protein kinase PGC1 peroxisome proliferators-activated receptor TRIB3 tribbles protein kinase 3 p-DRP1 phospho dynamin-related protein 1 GSK3 glycogen synthase kinase-3 beta NQO1 non-Q-dependent Reductase PDK1 pyruvate dehydrogenase kinase 1 LDH lactate dehydrogenase TCA cycle tricarboxylic acid cycle TCF4 T cell factor 4 ALOXE3 arachidonate lipoxygenase 3 HIC1 hypermethylated in cancer 1 LAMP-1 lysosomal associated membrane protein 1 SOD4 superoxide dismutase 4 GDF15 growth differentiation factor 15 LIP labile iron pool DRP1 dynamin-related protein 1 Camk2 calcium/calmodulin-dependent protein kinase II NQO1 non-Q-dependent Reductase TCA cycle tricarboxylic acid cycle;GPX4, glutathione peroxidase 4 OH hydroxyl radicals O 2 superoxide radicals GSSH oxidized glutathione DMT1 divalent metal transporter 1 LPO lipid peroxidation STAT1 transcription 1 COX-2 Cyclooxygenase-2 FTH1 ferritin heavy chain 1 API APG, apigenin Cyt c Cytochrome C Bax BCL2-Associated X Protein Bcl-2 B-cell lymphoma-2 HSP70 heat shock protein 70 NIR NearInfrared INF- interferon- PD-L1 programmed cell death ligand 1 DC dendritic cells DOX doxorubicin EGCG epigallocatechin-3-gallate NPs nanoparticles PL piperlongumine LDH lactate dehydrogenase SQS squalene synthase ACC acetyl-CoA carboxylase
