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Philip Morris International reported a 28 percent increase in the number of burnless tobacco products they shipped worldwide (compared to a slight decrease in traditional cigarettes). However, only three of the fifteen Southern states have defined or otherwise included these products in state code: Alabama, Mississippi, and Virginia. Other states, such as Louisiana and Missouri, define cigarettes in a way that could include burnless tobacco, but the definition is unclear

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Furthermore, there has been research to suggest that nicotine exposure primes the brain to become addicted to other substances

did a systemic overview and network metanalysis of research on tobacco use treatment medications, this review ultimately drew from hundreds of high-quality studies to make conclusions about the efficacy of tobacco use treatment medications.(2) They calculated the odds that a patient, given an exposure to a particular medication, would become tobacco free

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