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They produce the alpha-melanocyte stimulating hormone (alpha-MSH) that binds to the melanocortin 3 and 4 receptors (MC3Rs and MC4Rs) expressed by the second order neurons located in the periventricular nucleus and the lateral hypothalamic area (LHA) (51) (Figure 1)

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What is the recommended cross-taper protocol for a patient with anxiety, depression, and obsessive-compulsive disorder (OCD) who is currently taking Lexapro (escitalopram) 20mg, Seroquel (quetiapine) 200mg, and Trazodone 100mg, and wants to switch to Trintellix (vortioxetine) due to lack of response?