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P = 0.54

The final product (698 mg) was obtained in 54% yield and characterized by the analytic reversed-phase HPLC and 1 H NMR with a JEOL JNX-ECX500 spectrometer (Tokyo, Japan)

This principle is the fundamental reason why loading doses are necessary for drugs with very long half-lives such as for amiodarone with a t 1/2 of over 50 days

Beaulieu M, Levesque E, Tchernof A, Beatty BG, Belanger A, Hum DW

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New England Journal of Medicine (2025) The REDEFINE 2 Phase 3 trial evaluated CagriSema in 1,206 adults with overweight or obesity and type 2 diabetes in a 68-week, double-blind, placebo-controlled design