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During these reactions, GSH is converted into glutathione disulfide (GSSG: oxidized form of GSH)

In-vitro (Latin: in glass) refers to studies conducted outside of a living organism

Another open-label, randomized phase III inferiority study looked at mean A1c reduction in type 2 diabetics not controlled on metformin when treated with semaglutide or tirzepatide and tirzepatide was again found non-inferior (and even superior) in reducing A1c

Zhao Z, Liu T, Zhu S, Pi J, Guo P, Qi D, et al

Sci Rep 6(1):26859 [DOI] [PMC free article] [PubMed] [Google Scholar] Zota I et al (2024) Stimulating Myelin restoration with BDNF: a promising therapeutic approach for Alzheimers disease

In summary, the ferroptosis-related biological components discussed above are presented in Table 1 and Figure 1