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Immune dysregulation, which produces sterile inflammation, can be caused by distress, and toxic stress, as well as by autoimmune inflammatory diseases, intestinal dysbiosis, hypercaloric nutrition and junk food, obesity, sedentariness and indoor and outdoor pollution

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Two collagen types dominate: Type I collagen (mature tendon structure) Type III collagen (early repair phase) In rodent studies, BPC-157-treated tendons showed: Increased type I collagen deposition Improved fiber parallel alignment Better biomechanical strength This suggests influence over: TGF- signalling Matrix metalloproteinases (MMPs) Extracellular matrix remodelling enzymes Balanced ECM remodelling prevents disorganized scar tissue

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For general nutritional guidance, the RDI for adults is 2.4 mcg to 2.8 mcg per day