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49,82 In GERD patients, the expression of tight junction proteins between gastrointestinal epithelial cells is reduced, leading to increased gastrointestinal permeability

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For GI-specific applications, BPC-157 has been studied in two human trials for ulcerative colitis and multiple sclerosis, with no reported toxicity and an LD1 (lethal dose) that was never achieved in preclinical models

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