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According to global market research firm Euromonitor, the annual sales of conventional cigarettes worldwide dropped from approximately 5.96 trillion sticks in 2012 to 5.28 trillion in 2021a decline driven by increasingly stringent smoking regulations around the globe
Also, nicotine stimulates neutrophils to release neutrophil extracellular traps (NETs) in a dose-dependent manner
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Chronic exposure to smoke can also lead to desensitization of thirst receptors and disrupt the body's natural regulation of fluids and electrolytes
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