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When the volume of transplanted tumor reached approximately 150 mm 3 , mice were randomly divided into five groups (five mice per group), injected with PBS, MONs@MOF-199, free DOX/SOR, D/S@MM, and D/S@SPMM (5 mg DOX/kg and 1 mg SOR/kg) via tail vein once every three days within an interval of 21 days
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System Xc is composed of the solute carrier family 7 member 11 (SLC7A11) and the solute carrier family 3 member 2 (SLC3A2)