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Patients received 1,000 milligrams of a long-acting testosterone drug, called undecanoate, on the first day of the study, at week six, and then every three months

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Dashed arrows indicate negative feedback from circulating T 3 and T 4 to both the hypothalamus and pituitary gland, reducing TRH and TSH secretion

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doi: 10.1016/s0140-6736(15)00803-x 130 NewsomePNBuchholtzKCusiKLinderMOkanoueTRatziuVet al