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They found most had returned to their original weight within around 1.7 years and improvements in blood sugar, cholesterol and other metabolic markers also returned to baseline within roughly 1.4 years

Conclusion: While semaglutide is a well-established treatment with proven effectiveness for weight loss and diabetes management, retatrutide appears to offer an innovative approach with potentially higher weight loss efficacy due to its broader hormonal targeting

Published online March 13, 2026

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