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for about 15 years, we do not yet have enough information on their long-term health effects, so we must rely on shorter-term studies, molecular experiments and research in animals to try to assess the true risk of using e-cigarettes. But while the devices generate a vapor free of acrid smoke and tar, the heart and lung health experts at the AHA said they still know far too little about the effects of using the vape devices for years on end

alcohol (legal), cigarettes (legal), prescription drugs & coffee too much of it will have some sort of negative effect

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What it told me was this is not a situation of ignorance

doi: 10.1038/s41467-020-19320-9 341 XueW.XingY.WengX.ZhaoY.TangW.WangL.et al