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10.1016/j.molcel.2017.06.012 Mol
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While the body produces glutathione on its own, production can struggle to keep up during times of excess stress, immune challenges, unhealthy microbial environments, or during aging
This leads to the release of antimicrobial peptides, such as LL37, by stressed cells, which in turn prompts the release of DNA from both the stressed cell and the skin microbiome bacteria
Additionally, it is important to correct cobalamin deficiency before starting folic acid treatment, or provide cyanocobalamin together with folic acid
Whether that translates into sustained, equitable treatment uptake will depend on factors the science alone cannot resolve: cost, coverage, access, and clinical support.
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