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Glucose tolerance can worsen modestly, particularly in patients with pre-existing insulin resistance, and the label carries warnings against use in active malignancy, pregnancy, and in patients with hypothalamic-pituitary disorders

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14 (1), 8996 (2017) Snezhkina, A.V., Kudryavtseva, A.V., Kardymon, O.L., Savvateeva, M.V., Melnikova, N.V., Krasnov, G.S., et al.: ROS generation and antioxidant defense systems in normal and malignant cells

PMID: 18046911